5-Amino-1MQ: The NNMT Inhibitor in Fat-Metabolism Research
5-Amino-1MQ is a small-molecule inhibitor of nicotinamide N-methyltransferase (NNMT), an enzyme highly expressed in fat tissue. It is studied for how blocking NNMT shifts adipocyte metabolism toward greater energy expenditure.
Everything below is provided for research context only. This is a laboratory research compound — not a medicine, and nothing here is medical or dosing advice.
What Is 5-Amino-1MQ?
5-Amino-1MQ (5-amino-1-methylquinolinium) is a membrane-permeable small molecule, not a peptide. Its research interest centers entirely on NNMT inhibition.
How 5-Amino-1MQ Works in Research
NNMT consumes S-adenosylmethionine (SAM) and nicotinamide (a precursor in the NAD+ salvage pathway). By inhibiting NNMT, 5-Amino-1MQ is reported in preclinical work to:
- Spare nicotinamide and SAM, raising intracellular NAD+ and SAM.
- Increase adipocyte energy expenditure via “futile-cycling” metabolic pathways.
- Reduce fat mass and adipocyte size in diet-induced obese mice without reducing food intake, and improve glucose tolerance.
Where 5-Amino-1MQ Sits in Research
The evidence base is young and overwhelmingly in-vitro and rodent — there are no NNMT-targeting clinical trials, so no human or therapeutic claims apply. It links conceptually to NAD+ research (via the salvage pathway) and to metabolic tools like SLU-PP-332.
Handling in the Lab
- Supplied as a research powder; prepare stock solutions per your protocol and the compound’s solubility.
- Store cold and protected from light; minimize freeze-thaw cycles.
- Confirm identity and purity against the lot-matched Certificate of Analysis (HPLC / mass spec).
Frequently Asked Questions
What is 5-Amino-1MQ?
5-Amino-1MQ is a small-molecule inhibitor of the enzyme NNMT (nicotinamide N-methyltransferase), studied for effects on fat metabolism. It is supplied for laboratory research use only.
How does 5-Amino-1MQ work?
By inhibiting NNMT it spares nicotinamide and SAM, raising intracellular NAD+ and SAM and increasing adipocyte energy expenditure. In obese mice this reduced fat mass without changing food intake — research findings, not medical claims.
Is 5-Amino-1MQ a peptide?
No. It is a small-molecule NNMT inhibitor, not a peptide, though it is often studied alongside metabolic research compounds.
Does 5-Amino-1MQ raise NAD+?
In preclinical models, inhibiting NNMT spares nicotinamide (a NAD+ precursor) and is associated with higher intracellular NAD+. This is a research observation in cells and rodents, not a human claim.
Is 5-Amino-1MQ approved for human use?
No. It is an investigational research compound for laboratory use only. There are no NNMT-targeting clinical trials, and nothing here is medical advice.
References
Peer-reviewed research and recognized sources supporting the statements above, provided for research context only — not medical advice.
- Kraus D, et al. Nicotinamide N-methyltransferase knockdown protects against diet-induced obesity. Nature. View source →
- Neelakantan H, et al. Selective and membrane-permeable NNMT inhibitors reverse high-fat-diet-induced obesity in mice. Biochem Pharmacol. View source →
Research-grade 5-Amino-1MQ — third-party tested, certificate of analysis per lot, same-day US shipping.
Shop research-grade 5-Amino-1MQ →FOR LABORATORY AND RESEARCH USE ONLY. Golden State Bio supplies research-use-only chemicals for qualified researchers. Not for human or veterinary use; not evaluated by the FDA. Nothing here is medical advice.