NAD+: The Redox and Sirtuin Coenzyme in Longevity Research

NAD+ (nicotinamide adenine dinucleotide) is one of the most fundamental coenzymes in the cell — a carrier of electrons in energy metabolism and a required substrate for the sirtuin and PARP enzyme families. It sits at the center of a large body of aging and metabolic research.

Everything below is provided for research context only. This is a laboratory research compound — not a medicine, and nothing here is medical or dosing advice.

What Is NAD+?

NAD+ shuttles between its oxidized (NAD+) and reduced (NADH) forms in the reactions that extract energy from nutrients. Beyond redox chemistry, NAD+ is consumed by enzymes that regulate DNA repair (PARPs) and gene expression and metabolism (sirtuins).

Specifications

• Class: pyridine dinucleotide coenzyme
• CAS 53-84-9
• Format: lyophilized powder, reconstituted with bacteriostatic water for research
• Research focus: cellular energy metabolism, sirtuin/PARP activity, aging biology

How NAD+ Works in Research

• Redox: essential electron carrier in glycolysis, the TCA cycle, and oxidative phosphorylation.
• Sirtuins: NAD+ is the required cofactor for sirtuin deacetylases studied in metabolism and stress resistance.
• Aging: intracellular NAD+ declines with age in many tissues, which is why NAD+ biology and NAD+-boosting strategies are heavily studied in longevity research.

Where NAD+ Sits in Research

NAD+ connects to several metabolic research compounds — for example 5-Amino-1MQ, which spares the NAD+ precursor nicotinamide, and mitochondrial peptides like MOTS-c.

Handling in the Lab

• Ships as a lyophilized (freeze-dried) powder; reconstitute with bacteriostatic water using aseptic technique.
• Store the sealed powder cold and dark (long-term at -4°F); once reconstituted keep refrigerated at 36–46°F and use within a short window.
• Minimize freeze-thaw cycles and vial punctures.
• Judge quality by the lot-matched Certificate of Analysis (HPLC purity, mass-spec identity), not the label.

Frequently Asked Questions

What is NAD+?

NAD+ (nicotinamide adenine dinucleotide) is a coenzyme central to energy metabolism and a substrate for sirtuins and PARPs. It is supplied for laboratory research use only.

Why is NAD+ studied in aging research?

Intracellular NAD+ declines with age in many tissues, and it is required by sirtuins and DNA-repair enzymes, so NAD+ biology is a major focus of metabolic and longevity research.

What is the difference between NAD+ and NADH?

They are the oxidized (NAD+) and reduced (NADH) forms of the same coenzyme; the cell cycles between them to carry electrons during energy metabolism.

How does NAD+ relate to sirtuins?

Sirtuins are NAD+-dependent enzymes — they require NAD+ as a cofactor to remove acetyl groups from proteins, linking NAD+ levels to metabolic and stress-response signaling.

Is NAD+ approved for human use?

This product is supplied for laboratory research use only — not for human or veterinary use, and nothing here is medical advice.