SLU-PP-332: The ERRα Agonist Studied as an Exercise Mimetic
SLU-PP-332 is a small-molecule agonist of the estrogen-related receptors (ERRs), acting most strongly at ERRα. It has drawn attention in metabolic research as an “exercise mimetic” — a compound that switches on some of the same metabolic programs as physical activity.
Everything below is provided for research context only. This is a laboratory research compound — not a medicine, and nothing here is medical or dosing advice.
What Is SLU-PP-332?
Unlike most compounds in the research-peptide catalog, SLU-PP-332 is not a peptide — it is a synthetic small molecule. It is a pan-ERR agonist with the greatest potency at ERRα (reported EC50 around 98 nM).
Specifications
- Class: synthetic pan-ERR agonist (small molecule)
- CAS 303760-60-3 · molecular formula C18H14N2O2
- Primary target: ERRα (also ERRβ/γ)
- Research focus: mitochondrial/oxidative metabolism, metabolic syndrome models
How SLU-PP-332 Works in Research
ERRα is a nuclear receptor that acts as a master regulator of mitochondrial biogenesis and oxidative metabolism. By activating it, SLU-PP-332 is reported in rodent studies to:
- Increase whole-body energy expenditure and fatty-acid oxidation.
- Reduce fat-mass accumulation and improve insulin sensitivity in models of metabolic syndrome.
- Reproduce several exercise-associated metabolic adaptations without exercise.
Because it mimics endurance-type adaptations, it has also been flagged for potential doping relevance in sport-science literature.
Where SLU-PP-332 Sits in Research
It is an early-stage, preclinical research tool studied in obesity and metabolic-syndrome models. Researchers often study it alongside metabolic compounds such as 5-Amino-1MQ and the GLP agonists.
Handling in the Lab
- Supplied as a research powder; prepare stock solutions per your protocol and the compound’s solubility.
- Store cold and protected from light; minimize freeze-thaw cycles.
- Confirm identity and purity against the lot-matched Certificate of Analysis (HPLC / mass spec).
Frequently Asked Questions
What is SLU-PP-332?
SLU-PP-332 is a synthetic small-molecule pan-ERR agonist (strongest at ERRα) studied as an exercise mimetic in metabolic research. It is supplied for laboratory research use only.
Is SLU-PP-332 a peptide?
No. It is a small molecule (CAS 303760-60-3, C18H14N2O2), not a peptide — though it is often grouped with metabolic research compounds.
How does SLU-PP-332 work?
It activates ERRα, a regulator of mitochondrial biogenesis and oxidative metabolism. In rodent models this increased energy expenditure and fatty-acid oxidation and reduced fat mass — research findings, not medical claims.
What is an 'exercise mimetic'?
A compound that triggers some of the same metabolic adaptations as physical activity. SLU-PP-332 is studied in this context because ERRα activation overlaps with exercise-induced metabolic programs.
Is SLU-PP-332 approved for human use?
No. It is an investigational research compound for laboratory use only — not for human or veterinary use, and nothing here is medical advice.
References
Peer-reviewed research and recognized sources supporting the statements above, provided for research context only — not medical advice.
- Billon C, et al. The ERR agonist SLU-PP-332 mimics the metabolic effects of exercise. View source →
- In Vitro Metabolism and Analytical Characterization of SLU-PP-332: a Novel Pan-ERR Agonist. View source →
Research-grade SLU-PP-332 — third-party tested, certificate of analysis per lot, same-day US shipping.
Shop research-grade SLU-PP-332 →FOR LABORATORY AND RESEARCH USE ONLY. Golden State Bio supplies research-use-only chemicals for qualified researchers. Not for human or veterinary use; not evaluated by the FDA. Nothing here is medical advice.