TB-500: The Thymosin β4 Fragment in Tissue-Repair Research
TB-500 is a synthetic peptide based on the biologically active region of thymosin β4, a naturally occurring protein involved in cell repair and migration. It is one of the most-requested recovery-research peptides, frequently studied alongside BPC-157.
Everything below is provided for research context only. This is a laboratory research compound — not a medicine, and nothing here is medical or dosing advice.
What Is TB-500?
Thymosin β4 is a small protein whose actin-binding activity is concentrated in a short internal sequence. TB-500 corresponds to that active region, giving a stable, synthetic tool for studying the same pathways.
Specifications
- Class: synthetic peptide based on the active region of thymosin β4
- Key motif: the actin-binding sequence (LKKTETQ region) of Tβ4
- Format: lyophilized powder, reconstituted with bacteriostatic water for research
- Research focus: actin regulation, cell migration, angiogenesis, tissue repair
How TB-500 Works in Research
- Actin regulation: thymosin β4 is an actin-sequestering protein; the TB-500 fragment is studied for how it influences actin dynamics and cell motility.
- Cell migration & angiogenesis: studied for promoting the migration of cells involved in repair and for effects on new blood-vessel formation.
- Tissue repair: investigated in wound-healing and recovery models.
Where TB-500 Sits in Research
TB-500 is most often studied together with BPC-157 — the pairing behind the Wolverine Stack — and it is a component of the KLOW and Glow research blends.
Handling in the Lab
- Ships as a lyophilized (freeze-dried) powder; reconstitute with bacteriostatic water using aseptic technique.
- Store the sealed powder cold and dark (long-term at -4°F); once reconstituted keep refrigerated at 36–46°F and use within a short window.
- Minimize freeze-thaw cycles and vial punctures.
- Judge quality by the lot-matched Certificate of Analysis (HPLC purity, mass-spec identity), not the label.
Frequently Asked Questions
What is TB-500?
TB-500 is a synthetic peptide based on the active region of thymosin β4, studied for actin regulation, cell migration, and tissue repair. It is supplied for laboratory research use only.
How does TB-500 work in research?
Thymosin β4 is an actin-sequestering protein; TB-500 is studied for how it influences actin dynamics, cell migration, angiogenesis, and repair in models. These are research findings, not medical claims.
Is TB-500 the same as thymosin β4?
TB-500 is based on the active region of thymosin β4 rather than the full-length protein — a shorter, more stable research analog of the same activity.
Why are TB-500 and BPC-157 studied together?
They are investigated for complementary repair pathways, which is why they are frequently paired in recovery research and combined in blends like the Wolverine Stack and KLOW.
Is TB-500 approved for human use?
No. TB-500 is a research compound for laboratory use only — not for human or veterinary use, and nothing here is medical advice.
References
Peer-reviewed research and recognized sources supporting the statements above, provided for research context only — not medical advice.
- Goldstein AL, Hannappel E, Kleinman HK. Thymosin β4: actin-sequestering protein moonlights to repair injured tissues. Trends Mol Med. View source →
- Malinda KM, et al. Thymosin β4 accelerates wound healing. J Invest Dermatol. View source →
Research-grade TB-500 — third-party tested, certificate of analysis per lot, same-day US shipping.
Shop research-grade TB-500 →FOR LABORATORY AND RESEARCH USE ONLY. Golden State Bio supplies research-use-only chemicals for qualified researchers. Not for human or veterinary use; not evaluated by the FDA. Nothing here is medical advice.